Exploiting Lunar Natural and Augmented Thermal Environments for Exploration and Research

Near the poles of the Moon, there are permanently shadowed craters whose surface temperatures never exceed 100 K. Craters within craters, commonly referred to as double-shaded craters, have areas where even colder regions exist with, in many cases, temperatures that should never exceed 50 K. The presence of water ice possibly existing in permanently shaded areas of the moon has been hypothesized, discussed, and studied since Watson et al. [1] predicted the possibility of ice on the moon. Ingersoll et al. [2] estimated that the maximum sublimation rate for ice is less than 1 cm per billion years for these types of environments. These potential ice stores have many uses for lunar exploration, potentially providing precious water and rocket fuel for any human exploration or future colonization. The temperatures within these regions offer unprecedented high-vacuum cryogenic environments, which in their natural state could support cryogenic applications such as high-temperature superconductors and associated devices that could be derived. The potential application of naturally occurring cryogenic environments in conjunction with simple methods to augment these environments to achieve even colder temperatures opens the potential use of many additional cryogenic techniques. Besides ice stores and the potential for continuous solar illumination for power production, the unique cryogenic conditions at the lunar poles provide an environment that could reduce the power, weight, and total mass that would have to be carried from the Earth to the Moon for lunar exploration and research

In-Vivo Biodistribution and Safety of 99mTc-LLP2A-HYNIC in Canine Non-Hodgkin Lymphoma

Theranostic agents are critical for improving the diagnosis and treatment of non-Hodgkin Lymphoma (NHL). The peptidomimetic LLP2A is a novel peptide receptor radiotherapy candidate for treating NHL that expresses the activated α4β1 integrin. Tumor-bearing dogs are an excellent model of human NHL with similar clinical characteristics, behavior, and compressed clinical course. Canine in vivo imaging studies will provide valuable biodistribution and affinity information that reflects a diverse clinical population of lymphoma. This may also help to determine potential dose-limiting radiotoxicity to organs in human clinical trials. To validate this construct in a naturally occurring model of NHL, we performed in-vivo molecular targeted imaging and biodistribution in 3 normal dogs and 5 NHL bearing dogs. 99mTc-LLP2A-HYNIC-PEG and 99mTc-LLP2A-HYNIC were successfully synthesized and had very good labeling efficiency and radiochemical purity. 99mTc-LLP2A-HYNIC and 99mTc-LLP2A-HYNIC-PEG had biodistribution in keeping with their molecular size, with 99mTc-LLP2A-HYNIC-PEG remaining longer in the circulation, having higher tissue uptake, and having more activity in the liver compared to 99mTc-LLP2A-HYNIC. 99mTc-LLP2A-HYNIC was mainly eliminated through the kidneys with some residual activity. Radioactivity was reduced to near-background levels at 6 hours after injection. In NHL dogs, tumor showed moderately increased activity over background, with tumor activity in B-cell lymphoma dogs decreasing after chemotherapy. This compound is promising in the development of targeted drug-delivery radiopharmaceuticals and may contribute to translational work in people affected by non-Hodgkin lymphoma

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The Role of Gender in Entrepreneurial Leadership Skills Training

In recent years, the number of women-owned firms has expand-ed at 1½ times the rate of U. S. businesses overall. But given this impressive trend, women-owned businesses still generate fewer profits and revenues than businesses owned by men, and employ fewer people than male-owned firms. Prior research has offered several explanations for this trend including lower self-efficacy among women, type of firms owned by women, choice of industry in which they operate, work-life balance is-sues for women, and limited networks. A growing body of liter-ature also suggests that in order to establish sustainable and growth oriented ventures, entrepreneurs must develop and uti-lize leadership skills. Yet, little research has been conducted to investigate whether these skills develop the same way for both genders when using traditional and technologically-driven ap-proaches. In this research, we grapple with the challenge of how to effectively develop entrepreneurial leadership competen-cies among women. Using a quasi-experimental design, we empirically test the relationship, based on gender, between ped-agogy style and perceived leadership effectiveness. The results suggest that the use of game-based simulations that emphasize role play may be particularly valuable for improving the per-ceived effectiveness of women entrepreneurs